Causes of psoriasis

With the modern development of medicine and a lot of research carried out, scientists cannot fully determine the true causes of the development of scaly lichen. Psoriasis is a disorder of the skin and tissues surrounding the joints. The disease is characterized by a non-infectious course, with the appearance of papules and red spots, prone to fusion. These formations are dry, scaly, rise above the surface of the skin and represent a chronic, localized process. Microscopy reveals a significant number of keratinocytes, cells of the immune system (T-lymphocytes and macrophages), with abundant growth of the vascular network.

Psoriasis and its causes of occurrence, with this development of medicine, are being actively investigated, but no one determines the final cause of its occurrence.

Scientists identify several main bases for the development of pathology:

  • Genetics- the hereditary theory of the appearance of psoriasis is based on the fact that if ancestors or close relatives have this pathology, the risk of its appearance in subsequent generations is equal to 25% if one of the parents is sick. With the development of the disease in both parents, the risk of its occurrence in the offspring rises to 70%. It is possible that a healthy child is born to sick parents, but after a while, under the influence of the above factors, the disease develops in him.
  • Immune defect- Examining the histological material of patients with psoriasis, scientists have revealed an excessive accumulation of diseased immune cells in the layers of the epidermis. At the same time, specific antibodies were found, and in the surface layers of the epidermis - Munro microabscesses (accumulation of intercellular fluid, leukocytes, macrophages). A general blood test shows an increase in the number of leukocytes (T-helpers), this all speaks of the autoimmune nature of the disease.
  • Viral lesion- in this case, it means infection with retroviruses. This strain introduces its own tRNA chain into the host cell, replacing its genetic code with a viral one. Which manifests itself in excessive production and multiplication of immature and undifferentiated cells of the dermis.

An interesting fact is that antipsoriatic treatment according to the autoimmune theory is aimed at reducing the number of immune cells, including T-helpers. In the presence of psoriasis in HIV / AIDS-infected, the number of these cells decreases to the limit values, and the risk of developing psoriasis increases. Further investigation of this fact, can completely refute the autoimmune theory of the development of psoriasis.

Factors of psoriasis development

causes of psoriasis

What causes psoriasis? There are several provoking factors that negatively affect the body:

  • Stress- this factor is the trigger for psoriatic eruptions and the final link, under the influence of which the rash decreases. This factor is one of the main, since the onset of psoriasis in 50% of cases occurs precisely because of extreme fatigue, psychological trauma and nervous strain. With the onset of remission of psoriasis, any mental shock can provoke a relapse;
  • Infections- a group of diseases, with the development of which primary foci of psoriatic rash appeared. Such diseases include: all infectious diseases of the upper respiratory tract, bacterial and fungal infections affecting the skin, mononucleosis. In patients with psoriasis, the presence of an increased amount of pathogenic microflora (beta-hemolytic streptococcus and Staphylococcus aureus) was determined. Candidiasis is a fungal infectious process in which psoriasis develops most often;
  • External influence- quite a large number of patients associate the appearance of psoriasis as a result of external physical factors. Most often they are: mechanical trauma to the skin, burns, hypothermia and frostbite;
  • Endocrinopathies- this group of diseases is accompanied by impaired functioning of the body as a whole. This factor is most often found in the female sex, due to frequent changes in hormonal levels in connection with growing up, pregnancy, menstrual cycle, menopause. In patients with diabetes mellitus, metabolism is significantly disturbed, while a constant excess of glucose negatively affects human tissues and organs, provoking the development of other diseases;
  • Toxins- act as another cause of psoriasis on the body. Its appearance is associated with food poisoning, work in factories or factories, the abuse of certain products (citrus fruits, coffee, chocolate). Alcohol and smoking, with their toxic effects, provoke many diseases, including psoriasis;
  • The pathogenetic effect includestaking medications.It was proved that a small number of patients began to develop psoriasis while taking the following drugs: NSAIDs, beta-blockers, fortified drugs (vitamins of groups C, B, D), cytostatics, antibiotics (cephalosporins).

Prevention of psoriasis

Many factors contribute to the development of psoriasis. The basic theory has not yet been determined and any prevention measures should be comprehensive, comprehensively targeted. Patients should reconsider their lifestyle. If necessary, change your place of residence to a more environmentally friendly area.

It is recommended to avoid stressful situations. It is possible to take antidepressants and sedatives. The diet should include more fiber, non-allergenic fruits and vegetables, meat, fish. When treating concomitant pathologies, it is imperative to quit bad habits, consult a doctor about replacing therapy. Take courses of treatment in specialized sanatoriums.